ABSTRACT
A prospective study was undertaken to find out the benefit of immunosuppressive therapy(IV methyl prednisolone followed by oral prednisolone therapy for one year along with six doses of pulse monthly IV cyclophosphamide) in children with steroid resistant nephrotic syndrome. Thirty-four children with steroid resistant nephrotic syndrome were treated with above regime. The remission of the disease was determined at the end of first, second and third year. The above protocol could induce and maintain remission in 81.8% of children with minimal change nephrotic syndrome, 66.7% of children with diffuse mesangial proliferation and in only 16.7% of children with focal segmental glomerulosclerosis at the end of three years of the study. The therapy of IV methyl prednisolone followed by oral prednisolone for one year with 6 monthly pulse IV cyclophosphamide, is beneficial in children with steroid resistant minimal change disease and diffuse mesangial proliferative glomerulonephritis. The therapy is not effective in focal segmental glomerulosclerosis.
Subject(s)
Child , Child, Preschool , Cyclophosphamide/therapeutic use , Dose-Response Relationship, Drug , Drug Administration Schedule , Drug Resistance , Drug Therapy, Combination , Female , Follow-Up Studies , Humans , Infusions, Intravenous , Kidney Function Tests , Male , Methylprednisolone/therapeutic use , Nephrotic Syndrome/diagnosis , Prospective Studies , Recurrence , Risk Assessment , Severity of Illness Index , Survival Rate , Treatment OutcomeSubject(s)
Adult , Electrocardiography , Fatal Outcome , Female , Humans , India , Lutembacher Syndrome/diagnosis , Middle Aged , Mothers , Nuclear FamilyABSTRACT
Oral Metastasis from a carcinoma of the urinary Bladder is extremely uncommon. Two cases of transitional cell carcinoma of the Bladder, presenting eighteen and ten months after initial diagnosis, one with soft tissue metastasis in the upper alveolus and the other with bony metastasis to the mandible are discussed.
Subject(s)
Aged , Carcinoma, Transitional Cell/pathology , Gingival Neoplasms/secondary , Humans , Male , Mandibular Neoplasms/secondary , Maxilla/pathology , Middle Aged , Palate/pathology , Urinary Bladder Neoplasms/pathologyABSTRACT
During a ten year period, only three cases of extraskeletal myxoid chondrosarcoma were seen at Kidwai Memorial Institute of Oncology, South India. All were adults; the youngest patient was twenty-six years old and the oldest was seventy five years old. The tumours arose in the soft tissues of the extremities Our findings indicated that tumour size, site and morphology had no bearing on prognosis. With surgery radiotherapy and chemotherapy, two patients survived for four years and nine months respectively and one patient is still on follow up, five months after treatment.